Protein Design · Ovchinnikov Lab / Baker Lab
AF2-guided hallucination that co-folds target and binder — ~10 screens to a hit.
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5–30min
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About this model
BindCraft designs binders by hallucinating through AlphaFold2 while co-folding the target and candidate. Reported experimental hit rates need roughly ten screens rather than hundreds, and the whole pipeline is open source — which makes it the commercial-tier answer to RFDiffusion's licensing constraint.
Standardized I/O contract
Every model in the Hub speaks the same contract, which is what lets the Router and the agent call any of them without special-casing.
Inputs
Target structure (PDB)
Hotspot residues
Binder length
Outputs
All-atom coordinates in PDB format, viewable and downloadable.
Ranked binders with interface pAE, ipTM and shape complementarity.
