Protein Design · Baker Lab / Institute for Protein Design
De novo backbone generation by denoising diffusion — the binder-design workhorse.
5–30min
Runs on Managed GPU endpoint
Runs on managed compute. Availability and startup time depend on current capacity.Run this model
About this model
RFDiffusion generates protein backbones from noise, optionally conditioned on a target for binder design, a motif to scaffold, or a symmetry group. Experimentally validated against a wide range of targets. The standard first step of the design pipeline, followed by ProteinMPNN for sequences.
Standardized I/O contract
Every model in the Hub speaks the same contract, which is what lets the Router and the agent call any of them without special-casing.
Inputs
Target structure (PDB)
Contig map
Diffusion steps
Outputs
All-atom coordinates in PDB format, viewable and downloadable.
