Pathways · Database
g:Profiler
A web server for functional enrichment analysis and gene identifier conversion across biological databases.
What g:Profiler is
g:Profiler is a web server designed for functional enrichment analysis and the conversion of gene lists. It aids researchers in interpreting sets of genes by evaluating over-representation across established biological datasets and translating nomenclature between diverse systems.
The resource belongs to the pathway analysis domain, bringing together data from standard ontologies and curated biological pathway resources to support computational and experimental biology investigations.
How it is organised
The platform processes query lists of genes to assess functional enrichment against integrated reference databases, including Gene Ontology (GO), Reactome, WikiPathways, and the Human Phenotype Ontology (HPO). In addition to enrichment calculations, it processes gene lists to convert identifiers across different database namespaces.
Key facts
- Category
- Pathway
- Primary functions
- Functional enrichment analysis and gene identifier conversion
- Data sources included
- Gene Ontology (GO), Reactome, WikiPathways, Human Phenotype Ontology (HPO)
- Interface
- Web server
What you can use it for
- Pathway and ontology enrichment
- Assessing gene sets for statistically over-represented terms across Gene Ontology, Reactome, and WikiPathways.
- Phenotype annotation
- Examining gene lists against the Human Phenotype Ontology to identify associated phenotypic terms.
- Identifier mapping
- Converting gene identifiers between different namespace conventions and database formats.
Query it here
The research agent queries g:Profiler directly — no account, no API key — and every answer links back to the record it came from. Ask in plain language and it writes the query.
Strengths and limits
Good at
- Provides functional enrichment analysis alongside integrated gene identifier conversion in a single web resource.
- Draws from multiple biological annotation resources including Gene Ontology, Reactome, WikiPathways, and the Human Phenotype Ontology.
Watch out for
- KEGG and TRANSFAC datasets are excluded from the resource.
Questions
Can I search g:Profiler without writing code?
Yes. The research agent queries g:Profiler directly, with no account or API key, and cites the record behind every answer. Ask in plain language — for a gene, a protein, a compound or a study — and it builds the query for you.
Can I reuse data from g:Profiler?
Free to all users; annotations keep their source licences (GO CC BY 4.0, Reactome CC0, WikiPathways CC0, HPO custom). KEGG and TRANSFAC results are licence-restricted and are removed from every request made here. Terms: https://biit.cs.ut.ee/gprofiler/page/faq
Which reference databases are supported for enrichment analysis?
The server performs enrichment over Gene Ontology (GO), Reactome, WikiPathways, and the Human Phenotype Ontology (HPO), among others.
Are KEGG pathways available in g:Profiler?
No, KEGG is excluded from the platform.
Can g:Profiler convert gene names between formats?
Yes, it provides dedicated identifier conversion functionality for gene lists.
Written from g:Profiler's own website and reference material. Statements citing a figure that does not appear there are removed before publication. Licence and running details come from our registry.