Proteins · Database
UniProtKB
A reference database providing curated protein sequences and functional annotations for biological research.
What UniProtKB is
UniProtKB is a protein database that provides curated protein sequence records alongside functional annotation. It serves as a standardised reference vocabulary for proteins across biological disciplines.
The repository encompasses more than 250 million sequences, offering researchers an extensive collection of protein data.
How it is organised
UniProtKB compiles and curates protein sequences together with functional annotations to provide a standardised reference vocabulary for protein research.
Key facts
- Category
- Protein
- Records
- 250M+ sequences
- Content
- Curated protein sequence and functional annotation
What you can use it for
- Protein Sequence Retrieval
- Finding curated protein sequence data across a database of over 250 million records.
- Functional Annotation Lookup
- Examining curated functional details and standard reference terms associated with protein sequences.
Query it here
The research agent queries UniProtKB directly — no account, no API key — and every answer links back to the record it came from. Ask in plain language and it writes the query.
Strengths and limits
Good at
- Maintains an extensive collection exceeding 250 million protein sequences.
- Provides curated functional annotations alongside primary sequence data.
- Functions as a standard reference vocabulary for proteins.
Watch out for
- The web portal requires an up-to-date browser and will not display properly on older versions.
- Web interface access requires stable network connectivity to avoid page loading failures.
Questions
Can I search UniProtKB without writing code?
Yes. The research agent queries UniProtKB directly, with no account or API key, and cites the record behind every answer. Ask in plain language — for a gene, a protein, a compound or a study — and it builds the query for you.
Can I reuse data from UniProtKB?
CC BY 4.0. Terms: https://www.uniprot.org/help/license
What information is held in UniProtKB?
UniProtKB contains curated protein sequences and their corresponding functional annotations.
How many sequences are available in the database?
The database contains more than 250 million sequences.
What are the web browser requirements for the UniProt interface?
The web interface requires an up-to-date browser and a stable internet connection to load properly.
Written from UniProtKB's own website and reference material. Statements citing a figure that does not appear there are removed before publication. Licence and running details come from our registry.