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SettingsResearch demo · not for clinical or commercial use
Corollary
  1. Catalog
  2. Protein Structure
  3. ESM2-3B

Protein Structure · Meta FAIR

ESM2-3B

High-quality 1,280-dimensional protein embeddings for everything downstream.

Commercial use permittedThe MIT licence allows use in commercial research and products.MIT
Availability
On demand
Typical latency
900ms
Credits per run
~6
Compute tier
S · Micro

< 1s

Runs on On-demand GPU

Runs on our servers with on-demand compute. A first run needs time to load the model; active capacity can be reused and scales down when idle.

Run this model

ESM2-3B

Single-letter amino acid code. Whitespace and FASTA headers are stripped automatically.

Needs protein sequence

About this model

The 3B-parameter member of the ESM2 family. Its representations are the substrate for ESMFold, for the AminoWeb vector index, and for most downstream property predictors. Use the 3B checkpoint when embedding quality matters and the 150M when you are screening millions of sequences.

Standardized I/O contract

Every model in the Hub speaks the same contract, which is what lets the Router and the agent call any of them without special-casing.

Inputs

  • sequencesequence · required

    Protein sequence

Outputs

  • embeddingvector

    1,280-dimensional mean-pooled sequence representation.

Specification

Hardware
CPU only
GPU memory
16 GB
Version
2.0.0
Licence
MIT
Backend
On demandOn-demand GPU
MCP server
mcp-protein-server

Tasks

sequence embeddingvariant effect

Chains well with

  • Boltz-2Structure and binding affinity in one pass, approaching FEP accuracy 1000× faster.
  • ESMFoldSingle-sequence folding in seconds — no MSA, no waiting.

Source

  • Model card
embeddingprotein-lmmit-license