Genomics · Database
CIViC
An open, community-curated knowledgebase documenting the clinical relevance of cancer variants.
What CIViC is
CIViC (Clinical Interpretation of Variants in Cancer) is an open knowledgebase dedicated to the clinical relevance of cancer variants. It serves as an information resource for researchers and clinicians working in cancer genomics.
The resource collects and organises evidence concerning genomic alterations in cancer, relying on a community-curated model to document clinical interpretations.
How it is organised
The platform operates through open community curation, capturing and maintaining structured evidence records that interpret the clinical significance of cancer-associated genomic variants.
Key facts
- Full name
- Clinical Interpretation of Variants in Cancer
- Category
- Genomics
- Record type
- Curated cancer variant evidence
- Curation model
- Community-curated
What you can use it for
- Cancer variant interpretation
- Evaluating the clinical significance of specific genomic alterations identified in oncology specimens.
- Genomic evidence retrieval
- Searching curated records describing how specific cancer variants relate to clinical relevance.
- Collaborative curation
- Participating in the community-driven documentation and review of cancer variant interpretations.
Query it here
The research agent queries CIViC directly — no account, no API key — and every answer links back to the record it came from. Ask in plain language and it writes the query.
Strengths and limits
Good at
- Provides openly accessible, community-curated interpretations of cancer genomic variants.
- Directly links specific cancer variants to curated clinical evidence.
Watch out for
- Content development and updates depend on open community contributions.
- Focus is restricted to the clinical relevance of cancer variants rather than wider genomic variations.
Questions
Can I search CIViC without writing code?
Yes. The research agent queries CIViC directly, with no account or API key, and cites the record behind every answer. Ask in plain language — for a gene, a protein, a compound or a study — and it builds the query for you.
Can I reuse data from CIViC?
CC0 1.0. Curated evidence, levels A–E. An evidence item is a published claim, not a treatment recommendation. Terms: https://civic.readthedocs.io/en/latest/about/faq.html
What does the name CIViC stand for?
It stands for Clinical Interpretation of Variants in Cancer.
What types of data are included in CIViC?
CIViC contains curated evidence on the clinical relevance of cancer variants.
How are the database entries generated and maintained?
The database is maintained using an open, community-curated process.
Written from CIViC's own website and reference material. Statements citing a figure that does not appear there are removed before publication. Licence and running details come from our registry.