Genomics · Database
gnomAD
Population allele frequencies and gene constraint scores derived from exomes and genomes.
What gnomAD is
gnomAD is a genomics database that compiles population allele frequencies categorized by ancestry group, together with gene constraint scores.
How it is organised
The resource processes exome and genome sequencing data to compute allele frequencies across distinct ancestry populations and generate gene constraint scores.
Key facts
- Records
- v4 · 807k individuals
- Data types
- Exomes and genomes
- Category
- Genomics
What you can use it for
- Querying population allele frequencies
- Researchers can evaluate allele frequencies across different ancestry groups using aggregated exome and genome records.
- Assessing gene constraint
- Geneticists can inspect gene constraint scores calculated across human exome and genome datasets.
Query it here
The research agent queries gnomAD directly — no account, no API key — and every answer links back to the record it came from. Ask in plain language and it writes the query.
Strengths and limits
Good at
- Provides allele frequencies broken down across ancestry groups.
Questions
Can I search gnomAD without writing code?
Yes. The research agent queries gnomAD directly, with no account or API key, and cites the record behind every answer. Ask in plain language — for a gene, a protein, a compound or a study — and it builds the query for you.
Can I reuse data from gnomAD?
Open data with attribution; gnomAD browser code MIT. Some annotations shown alongside gnomAD (e.g. SpliceAI) are CC BY-NC 4.0. Terms: https://gnomad.broadinstitute.org/policies
What types of sequence data does gnomAD include?
The database includes data from both exomes and whole genomes.
What information does gnomAD report for genetic variants and genes?
It reports population allele frequencies broken down by ancestry group as well as gene constraint scores.
Written from gnomAD's own website and reference material. Statements citing a figure that does not appear there are removed before publication. Licence and running details come from our registry.