Multi-Modal Foundation · living-models
Botanic0-L
Plant genomic foundation model for regulatory annotation, expression analysis, and variant effect prediction.
What Botanic0-L is
Botanic0-L is a plant genomic foundation model developed by living-models. It is designed to assist biological researchers in interpreting plant genomes by learning representations of DNA sequences.
As the largest first-generation Botanic model, it addresses tasks in regulatory annotation, gene expression, and variant effect prediction. It is designed to be evaluated either zero-shot or following task-specific fine-tuning.
How it works
The model is built with a 40-layer architecture approaching one billion parameters. It serves as a foundation model for plant genomics, supporting inference directly in a zero-shot setting or adapted via fine-tuning for specific biological predictions.
Key facts
- Model type
- Plant genomic foundation model
- Architecture layers
- 40
- Parameter count
- Approaching 1 billion
- Release date
- February 2026
What you can use it for
- Regulatory Annotation
- Identifying and annotating functional regulatory regions across plant genomic sequences.
- Gene Expression Prediction
- Assessing expression profiles and transcriptional activity from sequence contexts zero-shot or through fine-tuning.
- Variant Effect Prediction
- Evaluating the functional impact of genetic variants within plant genomes.
Run it here
We list this model but cannot run it yet: gated on the Hub — never run past a gate the user did not accept.
Everything on this page still applies. Running it needs a loader for this repository, not a bigger machine.
Strengths and limits
Good at
- Functions effectively in zero-shot regimes as well as after task-specific fine-tuning.
- Provides a 40-layer scale approaching one billion parameters for learning complex plant genomic features.
Watch out for
- Requires custom code execution for deployment and evaluation.
- Documented evaluation is limited to regulatory annotation, expression, and variant effect tasks.
Inputs and outputs
You provide
Sequence or text
A protein or nucleotide sequence, or free text — whichever this model was trained on.
You get back
Mean-pooled representation, one vector per input.
Licence
Check the licence before commercial use · other
This model is gated by its authors — its licence has to be accepted on the source repository before it will run.
Questions
Can I use Botanic0-L commercially?
Check the licence before commercial use. This model is gated by its authors — its licence has to be accepted on the source repository before it will run.
What is Botanic0-L?
Botanic0-L is a 40-layer plant genomic foundation model built by living-models, approaching one billion parameters.
What tasks does Botanic0-L support?
It is designed for plant genomics tasks including regulatory annotation, gene expression estimation, and variant effect prediction.
Does Botanic0-L require fine-tuning for downstream tasks?
The model can be deployed zero-shot or fine-tuned on task-specific genomic datasets.
Written from Botanic0-L's own documentation (model card). Statements citing a figure that does not appear there are removed before publication. Licence and running details come from our registry.